Important Takeaways:

• It’s game of clones!
• The dire wolf — a species that disappeared 13,000 years ago and was made famous by the beloved HBO series “Game of Thrones” — is making a comeback, thanks to the first-ever so-called “de-extinction.”
• Three dire wolf pups — aptly named Romulus, Remus and Khaleesi — were successfully born using DNA from ancient dire wolf fossils and genes from their closest living relative, the gray wolf.
• The extraordinary results were revealed Monday by Colossal Biosciences, the same Texas-based genetic engineering company that created the adorable colossal woolly mouse.
• “Our team took DNA from a 13,000-year-old tooth and a 72,000-year-old skull and made healthy dire wolf puppies,” said Colossal CEO Ben Lamm. “It was once said, ‘any sufficiently advanced technology is indistinguishable from magic.’ Today, our team gets to unveil some of the magic they are working on and its broader impact on conservation.”
• To create the painfully cute pups, Colossal cloned high-quality cell lines using somatic cell nuclear transfer into donor egg cells, and transferred them to a surrogate dog mom, who gave birth in January, according to the statement.
• Lamm and George Church, a Harvard Medical School biologist, founded the now $10 billion private company with the goal of bringing back the wooly mammoth, Bloomberg reported.
• The company also has its eyes set on reviving the Tasmanian tiger, the dodo, and successfully genetically engineered the wooly mouse last month, which shares similar curly-haired features with wooly mammoths.

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