Researchers look ahead to the potential uses and benefits of self-copying RNA vaccine

Jab-Vaccine-Administered Self-amplifying RNA vaccines will add to the arsenal of conventional messenger RNA jabs. Credit: Pascal Pochard-Casabianca/AFP via Getty

Luke 21:11 There will be great earthquakes, and in various places famines and pestilences. And there will be terrors and great signs from heaven.

Important Takeaways:

  • Self-copying RNA vaccine wins first full approval: what’s next?
  • The endorsement last week by Japanese authorities of a jab against SARS-CoV-2 constructed using a form of RNA that can make copies of itself inside cells — the first ‘self-amplifying’ RNA (saRNA) granted full regulatory approval anywhere in the world — marks a pivotal advance.
  • Researchers have been trying to make saRNA vaccines a reality for more than 20 years.
  • “saRNA is a totally different beast.”
  • With approval for ARCT-154 secured in Japan, its developers are now seeking authorization in Europe; a regulatory decision is expected next year.

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