Tag Archives: “Delta plus”

Delta variant gains ground in U.S., men do worse with COVID-19

By Nancy Lapid

(Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

Highly contagious Delta variant gaining ground in U.S.

The highly transmissible Delta variant of SARS-CoV-2, first identified in India, has become the most prevalent variant among new COVID-19 cases in the United States, according to California-based genomics company Helix. The company’s computer models indicate that Delta now accounts for around 40% of new U.S. cases, Dr. William Lee, vice president of science at Helix, said in a statement provided to Reuters. The models, based on 27,717 virus samples from 687 counties across the United States, also indicated that the worrisome Gamma variant, first identified in Brazil, accounts for about 15% of new cases. Helix researchers have noted occasional cases of an “offspring” variant of Delta called Delta-plus, but they “aren’t seeing any evidence suggesting that these are driving the growth of Delta around the country yet,” Lee said. Earlier in June, the researchers reported on the medical website medRxiv ahead of peer review that the percentage of new COVID-19 cases due to the variant first identified in Britain, known as Alpha, had dropped from 70% in mid-April 2021 to 42% six weeks later. Now, Lee said, Alpha “is down to around 20%.” Lee said his team has submitted an update to the previous medRxiv preprint and is waiting for approval.

Regardless of health status, men do worse with COVID-19

Men appear more likely than women to experience severe outcomes from COVID-19 regardless of whether the men have underlying health conditions, according to a new study. Researchers in New York City who tracked roughly 5,000 patients of both sexes who were diagnosed in early 2020 found that men were sicker when first diagnosed and had a higher need for intensive care treatment and higher rates of death than women. This was true even though the men on average were younger and less likely than women to have risk factors such as obesity and high blood pressure that previously have been linked with poor COVID-19 outcomes. Among women, the likelihood of severe COVID-19 outcomes did seem to be related to their health status, the researchers said in a report published on Wednesday in the journal Communications Medicine. A second analysis of another group of roughly 1,600 patients in New York City diagnosed later in the year showed similar patterns. The authors noted that because their information on patients’ pre-existing medical problems may have been incomplete, larger studies are needed to confirm their findings and to explain the causes.

Moderna vaccine antibodies neutralize variants in lab study

The mRNA vaccine from Moderna Inc can defend against emerging variants with only modestly reduced effectiveness, laboratory experiments indicated. Moderna researchers studied blood serum obtained from eight volunteers who had received the second dose of the vaccine a week earlier. They found the vaccine had produced antibodies capable of neutralizing all variants, including additional versions of the Beta variant first identified in South Africa and three lineages of variants first identified in India, including the Kappa and Delta variants. The analysis did show some reduction of neutralization, by 2.1 fold against Delta, 3.3-3.4 fold against Kappa and 3.2 fold against Gamma, which was first identified in Brazil. “These new data are encouraging and reinforce our belief that the Moderna COVID-19 vaccine should remain protective against newly detected variants,” Moderna Chief Executive Stéphane Bancel said. The Moderna data was posted on Monday on the bioRxiv medical website ahead of peer review. Earlier in June, researchers reported in the journal Nature that the mRNA vaccine from Pfizer and BioNTech elicited antibodies that could neutralize all tested variants, including Delta, although at reduced strength.

(Reporting by Nancy Lapid and Mrinalika Roy; Editing by Will Dunham)

India says new COVID variant is a concern

By Uday Sampath Kumar and Bhargav Acharya

BENGALURU (Reuters) -India on Tuesday declared a new coronavirus variant to be of concern, and said nearly two dozen cases had been detected in three states.

The variant, identified locally as “Delta plus,” was found in 16 cases in the state of Maharashtra, Federal Health Secretary Rajesh Bhushan told a news conference.

The ministry said Delta plus showed increased transmissibility and advised states to increase testing.

On Monday, India vaccinated a record 8.6 million people as it began offering free shots to all adults, but experts doubted it could maintain that pace.

“This is clearly not sustainable,” Chandrakant Lahariya, an expert in public policy and health systems, told Reuters.

“With such one-day drives, many states have consumed most of their current vaccine stocks, which will affect the vaccination in days to follow.”

With the currently projected vaccine supply for the next few months, the maximum daily achievable rate is 4 to 5 million doses, Lahariya added.

The effort has so far covered about 5.5% of the 950 million people eligible, even though India is the world’s largest vaccine producer.

A devastating second wave during April and May overwhelmed health services, killing hundreds of thousands. Images of funeral pyres blazing in car parks raised questions over the chaotic vaccine rollout.

Since May, vaccinations have averaged fewer than 3 million doses a day, far less than the 10 million health officials say are crucial to protect the millions vulnerable to new surges.

VACCINE DRIVE FALTERING

Particularly in the countryside, where two-thirds of a population of 1.4 billion lives and the healthcare system is often overstretched, the drive has faltered, experts say.

Maintaining the pace will prove challenging when it comes to injecting younger people in such areas, Delhi-based epidemiologist Rajib Dasgupta said.

The capital is also facing difficulties. Authorities in New Delhi said more than 8 million residents had yet to receive a first dose and inoculating all adults there would take more than a year at the current pace.

India has been administering AstraZeneca’s vaccine, made locally by the Serum Institute of India, and a homegrown shot named Covaxin made by Bharat Biotech.

Last week, Serum Institute had said it planned to increase monthly production to around 100 million doses from July. Bharat now estimates it will make 23 million doses a month.

On Tuesday, television channel CNBC-TV18 reported that phase-3 data for Covaxin showed an efficacy of 77.8%.

India may also soon have a mass rollout of Russia’s Sputnik V vaccine, and the government expects to import vaccines this year from major makers such as Pfizer.

Although new infections in India have dropped to their lowest in more than three months, experts say vaccinations should be stepped up because of the transmissibility of new variants.

Over the past 24 hours India reported 42,640 new infections, the lowest since March 23, and 1,167 deaths.

Infections now stand at 29.98 million, with a death toll of 389,302, health ministry data showed.

(Reporting by Uday Sampath Kumar and Bhargav Acharya, Ankur Banerjee in Bengaluru, Shilpa Jamkhandikar in Pune; Writing by Neha Arora; Editing by Clarence Fernandez, Angus MacSwan and Giles Elgood)