More bombs hit Syria’s Ghouta after heaviest death toll in years

A helicopter is seen flying over the besieged town of Douma, Eastern Ghouta, Damascus, Syria February 20, 2018. REUTERS/Bassam Khabieh

BEIRUT (Reuters) – Pro-government forces pounded Syria’s eastern Ghouta on Tuesday, killing at least 66 people after the enclave’s heaviest one-day death toll in three years, a monitoring group said.

Sparking an international outcry, the surge in air strikes, rocket fire, and shelling has killed more than 210 adults and children in the rebel pocket near Damascus since late on Sunday, the Syrian Observatory for Human Rights said.

France described the government bombing as a serious violation of international humanitarian law.

There was no immediate comment from the Syrian military. Damascus says it only targets militants.

Recent violence in the besieged suburb is part of a wider surge in fighting on several fronts as President Bashar al-Assad’s military pushes to end the seven-year rebellion against him.

A U.N. coordinator called for an immediate ceasefire on Monday and said that Ghouta was “spiraling out of control” after an “extreme escalation in hostilities”.

In Geneva, the U.N. children’s agency expressed outrage at the casualties among the enclave’s children, saying it had run out of words.

Those killed since the escalation began on Sunday include 54 children. Another 850 people have been injured, the Britain-based Observatory said.

In Brussels, Syrian opposition leader Nasr al-Hariri – a delegation head at stalled U.N. peace talks – told the European Union the intensified attacks consisted a “war crime”, and pleaded for more international pressure on Assad to stop.

WARPLANES IN THE SKY

Rescuers said the air raids create “a state of terror” among residents in eastern Ghouta, where the United Nations says nearly 400,000 people live. The pocket of satellite towns and farms, under government siege since 2013, is the last major rebel bastion near the capital.

Factions in Ghouta fired mortars at Damascus on Tuesday, killing six people and injuring 28, Syrian state TV said. The army retaliated and pounded militant targets, state news agency SANA said.

The Syrian foreign ministry said militants in Ghouta were targeting Damascus and using people there as “human shields”. It said in a letter of complaint to the U.N. that some Western officials were denying the government’s right to defend itself.

The Civil Defence in eastern Ghouta, a rescue service that operates in rebel territory, said jets battered Kafr Batna, Saqba, Hammouriyeh, and several other towns on Tuesday.

“The warplanes are not leaving the sky at all,” said Siraj Mahmoud, a civil defense spokesman in Ghouta, as the sound of explosions rang out in the background.

Mahmoud said that government forces bombed houses, schools and medical facilities, and that rescuers had found more than 100 people dead “in one day alone” on Monday.

Reuters photos showed bandaged people waiting at a medical point in the town of Douma, some of them with blood streaming down their faces and their skin caked in dust.

Bombs struck five hospitals in the enclave on Monday, said the UOSSM group of aid agencies that funds medical facilities in opposition parts of Syria.

DE-ESCALATION ZONES

Assad’s most powerful backer, Russia, has been pushing its own diplomatic track which resulted in establishing several “de-escalation zones” in rebel territory last year.

Fighting has raged on in eastern Ghouta even though it falls under the ceasefire plans that Moscow brokered with the help of Turkey and Iran. The truces do not cover a former al-Qaeda affiliate, which has a small presence in the besieged enclave.

Residents and aid workers say the “de-escalation” deals have brought no relief. Food, fuel, and medicine have dwindled.

The two main rebel factions in eastern Ghouta, which signed the deals with Russia last summer, accuse Damascus and Moscow of using the jihadist presence as a pretext for attacks.

Moscow did not comment on the renewed bombing in eastern Ghouta on Tuesday.

Russian Foreign Minister Sergei Lavrov blamed on Monday “armed provocations” by Nusra militants, formerly linked to al-Qaeda, for conditions in Ghouta. He said Moscow and its allies could “deploy our experience of freeing Aleppo … in the eastern Ghouta situation”.

U.N. Syria envoy Staffan de Mistura warned on Tuesday that the escalating battle in Ghouta could turn into a repeat of the bloody fight for Aleppo, which Damascus regained full control of in late 2016 after years of fighting.

“These fears seem to be well founded,” aid group International Rescue Committee also said on Tuesday. It said malnutrition was widespread and Ghouta’s schools had been closed since early January because of the attacks.

“The people of Eastern Ghouta are terrified… There is nowhere safe for them to run to,” IRC’s Middle East Regional Director Mark Schnellbaecher said.

(Reporting by Angus McDowall, Ellen Francis, and Lisa Barrington; additional reporting by Tom Miles in Geneva; editing by Andrew Roche)

U.S. officials warn ‘intense’ flu season to continue, urge shots

: A box of masks is shown in the emergency room at Palomar Medical Center in Escondido, California, U.S., January 18, 2018. REUTERS/Mike Blake

(Reuters) – Adults who get a flu shot are 36 percent less likely to get the disease, while for children the figure was an unexpectedly high 59 percent, U.S. health officials said on Thursday, predicting that the current “intense” season could continue for weeks.

Anyone not already immunized should get a flu shot despite the lateness of the season, because “some protection is better than none,” one of the officials told a news briefing.

A total of 63 children in the United States have died of influenza this season, and three-quarters of them did not get a vaccine, said Anne Schuchat, acting director of the Centers for Disease Control and Prevention.

“This flu season continues to be extremely challenging and intense, with very high levels of office visits for flu and hospitalization rates, all indications that flu activity is high and likely to continue for several more weeks,” Schuchat said.

Flu symptom rates are close to those seen in the 2009 H1N1 flu pandemic and for the past few weeks the whole country has been experiencing the flu, she said.

The current vaccine’s effectiveness rate is based on an interim study conducted nationally through Feb. 3 covering thousands of people, Schuchat said.

Effectiveness against the season’s dominant strain, the H3N2 strain, was lower at about 25 percent. It was better against the other viruses, at 67 percent against H1N1 and 42 percent against influenza B viruses, she said.

Getting the shot can mean the difference between a mild illness and a hospital stay, Schuchat said, particularly for people at higher risk such as children and the aged.

“There’s still plenty of time. Go get a flu shot. Do it for yourself, your family and your community,” Health and Human Services Secretary Alex Azar told the briefing.

As many as 646,000 people are dying globally from seasonal influenza each year, U.S. health officials said in December, a rise from earlier assessments of the disease’s death toll.

(Reporting by Eric Walsh in Washington and Stephanie Kelly in New York; Editing by Lisa Shumaker)

Study in mice shows Zika virus also attacks adult brain cells

Aedes aegypti mosquitoes are seen inside Oxitec laboratory in Campinas, Brazil,

By Julie Steenhuysen

CHICAGO (Reuters) – U.S. researchers have found that Zika can attack special populations of brain cells in adult mice in the part of the brain involved in learning and memory, raising new questions about how the virus may be impacting millions of adults who have been infected with the virus.

The findings, published on Thursday in the journal “Cell Stem Cell,” are the first to look at whether Zika can attack the same kinds of cells in adult mice that they do in fetal mice.

Experts cautioned that the findings are preliminary and may not have any correlation to how Zika impacts human brain function, but they suggest the need for follow-up research.

“This is one potential consequence we need to look at,” said Dr. Joseph Gleeson, an expert in pediatric brain disease at The Rockefeller University in New York, who led the study.

Zika has already been shown to attack fetal brain cells known as neural progenitor cells – a type of stem cell that gives rise to various kinds of brain cells. The death of these cells is what disrupts brain development and leads to the severe birth defects seen in babies whose mothers were infected with Zika during pregnancy.

U.S. health officials have concluded that Zika infections in pregnant women can cause microcephaly, a birth defect marked by small head size that can lead to severe developmental problems in babies.

The connection between Zika and microcephaly first came to light last fall in Brazil, which has now confirmed more than 1,600 cases of microcephaly that it considers to be related to Zika infections in the mothers.

Fetal brains are chock full of neural progenitor cells, which are responsible for making cells that form key brain structures. Adults, whose brains are fully formed, have far fewer and there are some pockets remaining – including in the hippocampus, a part of the brain involved in memory and learning.

Gleeson wanted to see if Zika could attack these cells in adult mice. To find out, his team injected the virus into lab mice and examined their brains for Zika infection.

In the hippocampus, Gleeson said “it lit up like a Christmas tree and wiped out the stem cell population.”

“Based on our findings, getting infected with Zika as an adult may not be as innocuous as people think,” he said.

There have already been signs that Zika affects adult nerve cells. Several teams have published papers showing that in some patients, Zika can cause serious brain and spinal cord infections – including encephalitis, meningitis and myelitis – in people exposed to Zika.

In rare cases, Zika has also been linked with Guillain-Barre Syndrome, a post-infectious autoimmune disorder that can cause temporary paralysis in adults.

“It’s really unclear if this translates to human Zika infections,” said Dr. Daniel Pastula, a neurologist and medical epidemiologist at the University of Colorado Denver.

But if it does, it is not clear whether the effect is temporary or lasting.

“Detailed neurological studies are needed in infected humans to describe the effects of Zika virus infection on the brains of adults,” said Dr. Anna Checkley of the Hospital for Tropical Diseases, part of University College London Hospitals.

Gleeson said the study needs to be replicated by other scientists, and he wants to test other strains of Zika on adult mice at other times during an infection to see if those viruses have the same effect.

Since 2015, 66 countries and territories have reported evidence of vector-borne Zika virus transmission, according to the World Health Organization.

Earlier this month, researchers at Notre Dame University estimated as many as 93 million people across Latin America and the Caribbean could become infected with Zika in the current outbreak.

(Reporting by Julie Steenhuysen, editing by G Crosse)