Fauci bullish on prospects for U.S. vaccine, not worried about China winning race

By Julie Steenhuysen

(Reuters) – The leading U.S. expert on infectious diseases, Dr. Anthony Fauci, predicted on Wednesday the country will meet its goal of a coronavirus vaccine by year’s end and was unmoved by the prospect that China would get there first.

While there are no guarantees, “I feel good about the projected timetable,” Fauci told Reuters in an interview.

His comments follow promising early stage data for the Moderna Inc’s coronavirus vaccine, released on Tuesday, that was developed with scientists at the National Institute of Allergy and Infectious Diseases, which Fauci directs.

Many experts see a safe and effective vaccine as the only way out of the pandemic that has infected millions and killed more than 575,000 people worldwide.

Fauci said Moderna’s results were especially promising because the vaccine appeared to offer the type of protection seen in a natural infection.

In vaccine development, “one of the things that you hope for is that your vaccine induces a response that’s comparable to a natural infection, because theoretically, the best vaccine you could possibly ever get is a natural infection.”

Moderna’s candidate, which is set to enter the last stage of testing on July 27, is just one of more than a hundred vaccines in development globally, but only one of a few contenders that have earned millions of dollars in backing from Operation Warp Speed, the White House program that aims to deliver more than 300 million doses of a safe and effective COVID-19 vaccine by January.

Fauci, who has become a popular and trusted figure during the coronavirus outbreak, came under criticism from President Donald Trump and some of his Republican allies as Fauci cautioned against reopening the U.S. economy too soon.

Asked how he copes with the attacks on his character and allegiance to the president, Fauci told Reuters, “I don’t let it bother me. What we’re doing with vaccines, what we’re doing with therapeutics, what we’re doing with clinical trials is the real substance,” Fauci said.

VACCINE RACE

As U.S. states have begun to reopen businesses and coronavirus infections have soared, some White House officials have pointed fingers at China, where the virus first emerged late last year.

Fauci was unmoved by the prospect that China could cross the finish line first. Although he said he hopes China succeeds, he does not think they will win the vaccine race, at least not by much.

“I think everybody’s sort of on the same track.” If they do get there, he said, “They’re not going to get it particularly sooner than we get it. That’s for sure.”

Ultimately, he hopes multiple successful candidates prevail. “I don’t worry about anybody getting there first.”

Even if a vaccine succeeds in provoking an immune response, Fauci said it is still not clear how long that protection will last.

“These are questions that don’t have answers right now, because we’re only six months into the outbreak.” He said it may take a year before that immunity question is answered.

A recent Reuters poll found that a quarter of Americans are hesitant about taking a vaccine, voicing concern that the record pace of development could compromise safety. Fauci said he is aware of such concerns.

“It’s understandable, but unjustified,” he said. “We’re not compromising safety; we’re not compromising scientific integrity.”

Fauci said the normal development process of waiting for a vaccine to be proven effective before manufacturing begins wastes precious time.

“If the vaccine doesn’t work, the only thing you’ve lost is money.”

(Reporting by Julie Steenhuysen in Chicago; Editing by Lisa Shumaker)

‘A recipe for disaster,’ U.S. health official says of Americans ignoring coronavirus advice

By Susan Heavey and Doina Chiacu

WASHINGTON Reuters) – A spike in U.S. coronavirus infections is fueled in large part by people ignoring public health guidelines to keep their distance and wear masks, the government’s top infectious disease official said.

A daily surge in confirmed cases has been most pronounced in southern and western states that did not follow health officials’ recommendations to wait for a steady decline in infections for two weeks before reopening their economies.

“That’s a recipe for disaster,” Anthony Fauci, who directs the National Institute of Allergy and Infectious Diseases, told CNN in an interview broadcast on Monday.

“Now we’re seeing the consequences of community spread, which is even more difficult to contain than spread in a well-known physical location like a prison or nursing home or meatpacking place,” Fauci told the cable channel in the interview, which was recorded on Friday.

More than 2.5 million people have tested positive for the coronavirus in the United States and more than 125,000 have died of COVID-19, the respiratory illness it causes, according to a Reuters tally. The U.S. tally is the highest in the world while the global death toll in the pandemic surpassed half a million people on Sunday.

California ordered some bars to close on Sunday, the first major rollback of efforts to reopen the economy in the most populous U.S. state, following Texas and Florida ordering the closure of all their bars on Friday. Arizona and Georgia are among 15 states that had record increases in cases last week.

U.S. Vice President Mike Pence on Sunday pressed Americans to adopt face masks during a trip to Texas and wore one himself, a sharp turnaround for the administration. Republican President Donald Trump has refused to cover his face in public.

Pence and other top health officials were expected to visit Arizona and Florida later this week.

In places where cases are soaring, U.S. health officials are also considering “completely blanketing these communities with tests,” Fauci said, to try to get a better sense of an outbreak.

They would either test groups, or “pools,” of people or have community groups do contact tracing in person rather than by phone. Contact tracing involves identifying people who are infected and monitoring people who may have been exposed and asking them to voluntarily go into quarantine.

Fauci said that he was optimistic that a vaccine could be available by year’s end but that it was unclear how effective it would prove to be, adding that no vaccine would be 100% effective and citing challenges to achieve so-called herd immunity.

The top Republican in the U.S. House of Representatives, Kevin McCarthy, on Monday stressed individual actions to stop the spread of the virus, deflecting criticism from Democrats and some health experts that Trump botched the prevention effort.

“You can’t say the federal government should do everything, and then say the federal government can’t tell the states what to do,” McCarthy told CNBC. “The governors have a big responsibility here but every American has a responsibility. They should wear a mask.”

(Reporting by Susan Heavey and Doina Chiacu in Washington; Writing by Grant McCool; Editing by Howard Goller)

Explainer: What is a second wave of a pandemic, and has it arrived in the U.S.?

By Julie Steenhuysen

CHICAGO (Reuters) – Infectious disease experts, economists and politicians have raised concerns about a second wave of coronavirus infections in the United States that could worsen in the coming months.

But some, including Dr. Anthony Fauci, the U.S. government’s top infectious disease expert, said it is too soon to discuss a second wave when the United States has never emerged from a first wave in which more than 120,000 people have died and more than 2.3 million Americans have had confirmed infections with the novel coronavirus.

Here is an explanation of what is meant by a second wave.

WHY DESCRIBE DISEASE OUTBREAKS AS WAVES?

In infectious disease parlance, waves of infection describe the curve of an outbreak, reflecting a rise and fall in the number of cases. With viral infections such as influenza or the common cold, cases typically crest in the cold winter months and recede as warmer weather reappears.

Fears about a second wave of COVID-19, the respiratory disease caused by the coronavirus, stem in part from the trajectory of the 1918-1919 Spanish flu pandemic that infected 500 million people worldwide and killed an estimated 20 to 50 million people. The virus first appeared in the spring of 1918 but appears to have mutated when it surged again in the fall, making for a deadlier second wave.

“It came back roaring and was much worse,” epidemiologist Dr. William Hanage of Harvard University’s T.H. Chan School of Public Health said.

Epidemiologists said there is no formal definition of a second wave, but they know it when they see it.

“It’s often quite clear. You’ll see a rise involving a second group of people after infections in a first group have diminished,” epidemiologist Dr. Jessica Justman of Columbia University’s Mailman School of Public Health said.

U.S. COVID-19 cases spiked in March and April and then edged downward in response to social-distancing policies aimed at slowing the transmission of the virus from person to person. But unlike several countries in Europe and Asia, the United States never experienced a dramatic drop in cases marking the clear end of a first wave. There is now a plateau of about 20,000 U.S. cases daily.

“You can’t talk about a second wave in the summer because we’re still in the first wave. We want to get that first wave down. Then we’ll see if we can keep it there,” Fauci told the Washington Post last week.

The easing in recent weeks of social-distancing mandates in numerous U.S. states as businesses have reopened has caused an acceleration in infections.

IS TALK OF WAVES JUST SEMANTICS?

To many epidemiologists, it is a matter of semantics.

“Do you want to call it an extension of the first wave or a second wave superimposed on the first? You could argue it either way,” Justman said.

Dr. Eric Toner, a senior scientist at the Johns Hopkins Center for Health Security, said he does not find “waves” to be an especially useful term in describing a pandemic.

“When you’re underwater, it’s hard to tell how many waves are passing over your head,” Toner said.

Toner said current increases in U.S. cases have less to do with the virus and more to do with people’s behavior.

“The virus isn’t going away and coming back. The virus is still here. It’s up in some places and down in others,” Toner said.

WHAT IS THE FORECAST FOR THE COMING MONTHS?

Vice President Mike Pence last week wrote an opinion piece in the Wall Street Journal trying to ease concerns over a second wave of U.S. cases. White House economic adviser Larry Kudlow said on Monday that a “second wave” is not coming.

Dr. Theo Vos of the University of Washington’s Institute for Health Metrics and Evaluation called those assurances “wishful thinking.”

Based on global models, his group has predicted that the coronavirus will surge in the fall as colder temperatures arrive in the United States.

“It’s likely to start picking up in October,” Vos said, with increased cases hitting in November, December and January.

(Reporting by Julie Steenhuysen; Editing by Peter Henderson and Will Dunham)

‘There is a real risk’ of new outbreak if U.S. states reopen too soon: Fauci

By Makini Brice and Richard Cowan

WASHINGTON (Reuters) – Leading U.S. infectious disease expert Anthony Fauci on Tuesday warned Congress that a premature lifting of lockdowns could lead to additional outbreaks of the deadly coronavirus, which has killed 80,000 Americans and brought the economy to its knees.

Fauci, director of the National Institute of Allergy and Infectious Diseases, told a U.S. Senate panel that states should follow health experts’ recommendations to wait for signs including a declining number of new infections before reopening.

President Donald Trump has been encouraging states to end a weeks-long shuttering of major components of their economies. But senators heard a sobering assessment from Fauci, when asked by Democrats about a premature opening of the economy.

“There is a real risk that you will trigger an outbreak that you may not be able to control and, in fact paradoxically, will set you back, not only leading to some suffering and death that could be avoided but could even set you back on the road to try to get economic recovery,” Fauci said.

The COVID-19 respiratory disease caused by the new coronavirus has infected more than 1.3 million Americans and killed more than 80,600.

Fauci, a member of Trump’s coronavirus task force, told the Senate Health, Education, Labor and Pensions Committee that the nation’s efforts to battle the deadly virus and the COVID-19 disease it triggers should be “focused on the proven public health practices of containment and mitigation.”

Fauci, 79, testified remotely in a room lined with books as he self-quarantines after he may have come into contact with either of two members of the White House staff who were diagnosed with COVID-19. He noted that he may go to the White House if needed.

“All roads back to work and back to school run through testing and that what our country has done so far on testing is impressive, but not nearly enough,” Lamar Alexander, the Republican chairman of the Senate committee, said in an opening statement to Tuesday’s hearing.

Alexander is also self-quarantining in his home state of Tennessee for 14 days after a member of his staff tested positive. Alexander chaired the hearing virtually.

Democrats on the health committee largely concentrated on the risks of opening the U.S. economy too soon, while Republicans downplayed that notion, saying a prolonged shutdown could have serious negative impacts on people’s health and the health of the economy.

Trump, who previously made the strength of the economy central to his pitch for his November re-election, has encouraged states to reopen businesses that had been deemed non-essential amid the pandemic.

His administration has largely left it to states to decide whether and how to reopen. State governors are taking varying approaches, with a growing number relaxing tough restrictions enacted to slow the outbreak, even as opinion polls show most Americans are concerned about reopening too soon.

Senator Patty Murray, the senior committee Democrat, criticizing aspects of the administration’s response to the pandemic, said Americans “need leadership, they need a plan, they need honesty and they need it now, before we reopen.”

Others testifying on Tuesday included U.S. Centers for Disease Control and Prevention Director Robert Redfield, Assistant Secretary for Health Brett Giroir and Food and Drug Administration Commissioner Stephen Hahn. Each testified remotely.

Meanwhile, House Majority Leader Steny Hoyer, a Democrat, told reporters that a Democratic bill to provide significant new federal aid in response to the coronavirus pandemic could be unveiled later on Tuesday, with a possible House of Representatives votes on it on Friday.

(GRAPHIC: Tracking the novel coronavirus in the U.S. – https://graphics.reuters.com/HEALTH-CORONAVIRUS-USA/0100B5K8423/index.html)

(Reporting by Richard Cowan, Makini Brice, Doina Chiacu and Tim Ahmann; Editing by Scott Malone and Alistair Bell)

No plans to separate Trump, Pence despite White House coronavirus cases: source

WASHINGTON (Reuters) – The Trump administration has no plans to keep President Donald Trump and Vice President Mike Pence apart, a person familiar with the matter said on Sunday, as concerns rise about the spread of the coronavirus within the White House.

The New York Times first reported the lack of plans to keep Trump and Pence separated despite concern they both could be incapacitated by the disease, citing two senior administration officials.

The White House did not respond to a request for comment.

Two coronavirus cases in the White House last week spurred fears of contagion for the president and vice president, who are leading the U.S. response to the pandemic, and who have both resumed travel and business schedules even as the U.S. death toll from the virus nears 80,000.

Pence’s press secretary, Katie Miller, the wife of Trump’s senior adviser, Stephen Miller, tested positive for the coronavirus a day after confirmation that Trump’s personal valet had been diagnosed with the disease.

White House Press Secretary Kayleigh McEnany sought on Friday to defend administration efforts to protect Trump and Pence, pointing to new measures taken by the White House including contact tracing and putting in place all guidelines recommended for essential workers.

The White House has also instituted daily coronavirus tests for Trump and Pence.

Anthony Fauci, a high-profile member of the White House coronavirus response team, Robert Redfield, director of the U.S. Centers for Disease Control and Prevention, and U.S. Food and Drug Administration Commissioner Stephen Hahn, were in self-quarantine on Saturday after coming into contact with someone who had tested positive for the disease.

If Republicans Trump and Pence were both to become incapacitated, Democratic House of Representatives Speaker Nancy Pelosi would assume presidential duties under U.S. law.

Last month, British Prime Minister Boris Johnson was admitted to an intensive care unit after becoming the first leader of a major power to announce he had tested positive for the highly contagious respiratory virus. Foreign Secretary Dominic Raab deputized for Johnson during his convalescence.

(Reporting by Alexandra Alper; Editing by Peter Cooney)

U.S. coronavirus expert Fauci: ‘Now is no time to back off’

By Doina Chiacu

WASHINGTON (Reuters) – The top U.S. infectious disease expert warned on Friday that even though hard-hit spots like New York are showing positive results in the battle against the coronavirus, it is too early to relax restrictions on Americans.

The warning from Dr. Anthony Fauci came as President Donald Trump administration’s top economic officials said on Thursday they believe the U.S. economy could start to reopen for normal business in May, despite health experts’ urging to continue social distancing to defeat the coronavirus.

Trump, a Republican seeking re-election on Nov. 3, has made clear he wants to get the economy going as soon as possible.

“Hopefully we’re going to be opening up… very, very, very, very soon, I hope,” he said on Thursday at the White House’s daily coronavirus briefing.

Fauci warned against relaxing restrictions too soon.

“What we’re seeing right now are some favorable signs,” Fauci said in an interview on CNN, citing progress in hard-hit New York.

Before moving to reopen society, he added: “We would want to see a clear indication that you were very, very clearly and strongly going in the right direction. Because the one thing you don’t want to do is you don’t want to get out there prematurely and you wind up back in the same situation.”

In New York, authorities said on Thursday the number of newly hospitalized patients in dropped for a second day, to 200, even though the number of coronavirus-related deaths in the state rose by 799 on Wednesday.

“You can’t relax,” Governor Andrew Cuomo said.

With many Americans celebrating the Easter holiday on Sunday, Fauci said it was important to keep social distancing measures in place.

“Now is no time to back off,” Fauci said.

Members of the coronavirus task force look at data every day for indications “we can go forward in a gradual way to essentially reopening the country,” Fauci said, and report back to Trump and Vice President Mike Pence. “That decision will be made at that level,” he said.

 

(Reporting by Doina Chiacu; Editing by Chizu Nomiyama)