Tag Archives: Pandemic

U.S. screens highest number of airline passengers since March

By David Shepardson

WASHINGTON (Reuters) – The U.S. Transportation Security Administration said it screened 1.047 million passengers on Sunday, the highest number since mid-March.

The number of U.S. air travelers is still nearly 60% lower than the same date last year but Sunday was the second time in three days that passengers screened topped 1 million.

The Centers for Disease Control and Prevention (CDC) on Thursday urged Americans not to travel during this week’s Thanksgiving holiday to mitigate the spread of the coronavirus as cases of COVID-19 spike around the United States.

There have been just three days since March 16 that the number of U.S. airline passengers screened topped 1 million, with the first being Oct. 18 when it was 1.031 million.

Delta Air Lines and Southwest Airlines have cautioned that the recent surge in COVID-19 cases may have a negative impact on travel over the winter holidays, a period the sector had hoped would see improved bookings.

U.S. airlines say travel demand remains down 62%, while international travel demand remains down more than 70%. Some officials think U.S. restrictions barring many non-U.S. citizens from arrival could be eliminated or reduced with new testing.

The CDC on Saturday said COVID-19 testing before and after international travel can reduce risk and “make travel safer by reducing spread on planes, in airports, and at destinations.”

On Wednesday, the chief executives of the seven largest U.S. airlines made a fresh plea for more payroll relief in a letter to congressional leaders.

American Airlines and United Airlines last month furloughed 32,000 workers.

The COVID-19 pandemic brought travel to a near halt earlier in the year, forcing airlines to scale back operations and seek government bailouts.

(Reporting by David Shepardson; Editing by Toby Chopra and Andrea Ricci)

U.S. officials worry about holiday spike as coronavirus surges

By Brendan O’Brien and Maria Caspani

CHICAGO (Reuters) – U.S. health authorities braced for further increases in COVID-19 infections, hospitalizations and deaths on Friday, capping a week in which the spread of the novel coronavirus accelerated ahead of next week’s Thanksgiving holiday.

The seven-day rolling average of new COVID-19 cases reached more than 165,000 on Thursday, while the seven-day average for deaths climbed to 1,359, more than any day since late May, according to a Reuters tally of public health data.

With hospitalizations rising across much of the nation, straining already exhausted medical staff, officials in more than 20 states have imposed restrictions to curtail the spread of the virus.

The White House Coronavirus Task Force coordinator, Dr. Deborah Birx, said the virus is spreading at a high rate across more than half the country and that Thanksgiving gatherings should be limited to immediate family members rather than a maximum number of people.

“I don’t like it to be any number… if you say it can be 10, and it’s eight people from four different families, then that probably is not the same degree of safe as 10 people from your immediate household,” Birx told CNN on Friday.

In a positive sign for combating the pandemic, Pfizer Inc. said it will apply to U.S. health regulators on Friday for emergency use authorization of its COVID-19 vaccine, the first such application in a major step toward providing protection against the virus.

Pfizer and German partner BioNTech SE this week reported final trial results that showed the vaccine was 95% effective in preventing COVID-19 with no major safety concerns.

If the data is solid, “we literally could be weeks away from the authorization of a 95% effective vaccine,” U.S. Health Secretary Alex Azar said on CBS’ “This Morning.”

California’s governor on Thursday imposed some of the most stringent restrictions on the vast majority of the state’s population, with a curfew on social gatherings and other non-essential activities that will start on Saturday night and end on the morning of Dec. 21.

“The virus is spreading at a pace we haven’t seen since the start of this pandemic, and the next several days and weeks will be critical to stop the surge,” Governor Gavin Newsom, a Democrat, said in a statement announcing the measure a week before the Thanksgiving holiday.

Similar restrictions took effect in Ohio this week, while Minnesota ordered a shutdown of restaurants, bars, fitness centers and entertainment venues from Friday until Dec. 18 at the earliest, as the state’s hospital intensive care units were stretched to capacity.

In Illinois, where the number of COVID-19 tests coming back positive was at an alarmingly high 20% and new restrictions, including a ban on indoor dining, took effect on Friday, long lines appeared again at testing sites.

In Chicago’s metro area, Emily Randall had no luck finding an opening to get tested after she woke up with a throbbing headache on Thursday.

“It’s very frustrating because I’m trying to be a responsible citizen,” said the 43-year-old research analyst. “My head feels a lot better but I am still worried because I have read stories of people who got better and then, all of a sudden, got worse.”

The number of patients hospitalized with COVID-19 in the United States has jumped nearly 50% in the past two weeks, with more than 80,000 people being treated for the disease in hospitals across the country as of late Thursday, a Reuters tally showed, the most at any time during the pandemic.

Daily COVID-19 deaths surpassed the 2,000 mark for the first time since late June on Thursday.

THANKSGIVING FEARS

U.S. officials have pleaded with the public to avoid unnecessary travel and exercise caution as the winter holidays of Thanksgiving and Christmas approach.

The U.S. Centers for Disease Control and Prevention issued a “strong recommendation” on Thursday that Americans refrain from traveling for the holiday.

Although COVID-19 restrictions have received more bipartisan support from state leaders in recent weeks, South Dakota Governor Kristi Noem, a Republican and close ally of President Donald Trump, refused to limit gatherings on Thanksgiving.

“In South Dakota, we won’t stop or discourage you from thanking God and spending time together this Thanksgiving,” Noem said in a statement on Friday.

With cases and deaths increasing steadily in most states, the University of Washington’s Institute for Health Metrics and Evaluation updated its widely cited model.

It now projects 471,000 coronavirus deaths by March 1, up from less than 440,000 in its previous forecast.

In hard-hit Wisconsin, the state’s hospital association implored lawmakers to address the growing crisis by providing more resources to health care workers and facilities.

“With few tools available right now to curb spread other than increasingly urgent public appeals, our COVID numbers are growing rapidly and predict, quite accurately so far, a health care crisis in Wisconsin that without significant, swift, and unified action will become a catastrophe,” Wisconsin Hospital Association President and CEO Eric Borgerding wrote in a letter to legislators and the governor on Thursday.

(Reporting by Maria Caspani in New York and Brendan O’Brien in Chicago; additional reporting by Anurag Maan in Bengaluru, Sharon Bernstein in Sacramento and Steve Gorman in Los Angeles, California; Editing by Dan Grebler)

‘Dial back’ or ’emergency brake?’ New lockdowns and the U.S. economy

SAN FRANCISCO (Reuters) – The surge in new COVID-19 infections is driving a fresh wave of restrictions in cities and counties across the United States.

California’s “emergency brake,” Oregon’s “freeze,” Philadelphia’s “safer at home” and Minnesota’s “dial back” are among a new patchwork of rules adopted by states, cities and counties that are much less strict and far more narrow than measures imposed to stop the spread of the virus in the spring.

The overall economic bite will be smaller, too, compared to the downdraft that started earlier this year and which led to roughly 22 million people losing their jobs, a collapse in retail spending and a recession.

“I don’t see where you get a 30% hit to GDP,” said Tim Duy, an economics professor at the University of Oregon. “There’s not as much to take off the table … I’m having a hard time seeing where you are going to derail the recovery.”

Businesses that were fully shut in March, like medical offices, shops, factories, and even hair salons, will remain open in many areas this time around.

That’s in part because many Americans have changed their behavior, businesses from manufacturers to retail stores have added routine temperature checks, and face masks are more common and in many states mandated. Meanwhile, consumers have embraced online shopping and curbside delivery to keep spending.

High-frequency data backs that up: even after the latest explosion in case numbers, economic activity has not collapsed.

SURGICAL STRIKE

Many of the latest restrictions target activities where science shows the spread of the virus is the most pernicious – indoor pursuits, in close quarters, for extended periods of time, or with heavy or unmasked breathing.

That means they will hurt some already hard-hit sectors of the economy, including hospitality and entertainment. The U.S. Centers for Disease Control and Prevention on Thursday issued a strong recommendation against travel over the Thanksgiving holiday this month, though it did not ban it outright.

Many of the more than two dozen states that have issued new restrictions this week have closed or restricted indoor dining and gyms. California, the biggest state by economic output, is among that group.

At the same time, businesses shut during California’s lockdowns in the spring, including shopping malls, body waxing venues, and barber shops, can continue to operate, albeit with some limits to contain the spread of the virus.

Philadelphia’s ban on indoor dining goes into effect on Friday.

Stock Fishtown and Stock Rittenhouse, which are owned by Philadelphia-based restaurateur Tyler Akin, will shift to carry-out and delivery mode. On Monday new rules in Delaware will force him to reduce capacity at his Le Cavalier restaurant in Wilmington to 30%, down from the current 50%. Though better than being entirely closed down, as was the case in March, Akin may need to adjust staffing to fit revenue.

“We have some really hard conversations ahead of us,” he said.

Efforts to adapt business to the realities of the pandemic may allow some restaurants and bars to weather the worst effects of the restrictions. In Oakland, California, as in many cities around the country, restaurants and bars have built platforms decked out with tables, chairs and propane heaters to make customers more comfortable outside in chillier weather.

It’s “a way to keep our businesses afloat,” said Ari Takata-Vasquez, who leads a small-business alliance in Oakland that has raised money to build the outdoor dining areas for cash-strapped eateries.

She’s working on, or completed, five of them – and has 30 eateries and gyms on the waiting list.

In Minnesota, movie theaters and yoga studios will shut at midnight on Friday, along with indoor and outdoor service at eateries, pubs and gyms. Minnesota Governor Tim Walz, like many of his counterparts across the country, is also telling families not to have household gatherings, and he acknowledged the new rules will be felt especially hard by small businesses.

“By closing your doors and putting your financial well-being at risk, you are protecting the lives of your neighbors,” he said this week.

LIGHTER LOCKDOWNS, LESS RELIEF

Many of the newly implemented restrictions are expected, at least for now, to last two to four weeks. But even though lockdowns will be more moderate – and in many places are simply sector-specific curfews rather than sweeping closures – business owners and employees, especially in the restaurant industry, are worried their own financial pain will be sharper.

That’s because Congress has shown little sign of delivering another round of fiscal relief, let alone the massive pandemic packages totaling some $3 trillion passed earlier this year.

The last of the extra government aid for the unemployed is due to run out at the end of this year. A bill with bipartisan support to rescue the restaurant industry is caught in limbo in Congress, as the outgoing Trump administration focuses on challenging the results of the Nov. 3 presidential election.

While households overall still have excess savings, built in part from prior government aid, for many families that money is likely to run out before a vaccine comes into widespread use.

(Reporting by Ann Saphir and Jonnelle Marte and Howard Schneider; Editing by Paul Simao)

Mnuchin says Main Street U.S. companies need grants, not loans

By Andrea Shalal and David Lawder

WASHINGTON (Reuters) – U.S. Treasury Secretary Steven Mnuchin on Friday defended his decision to end several of the Federal Reserve’s key pandemic lending programs on Dec. 31, saying Congress should use the money to help small U.S. companies with grants instead.

Federal Reserve Chairman Jerome Powell and Chicago Federal Reserve Bank President Charles Evans have criticized the Treasury move, saying the programs – while not being used extensively – provided an important backstop for the economy.

Mnuchin told Powell in a letter Thursday that the $455 billion allocated to Treasury under the CARES Act last spring, much of it set aside to support Fed lending to businesses, nonprofits and local governments, should be made available for Congress to reallocate.

Speaking on CNBC, Mnuchin said Congress had always intended for the lending programs to end on Dec. 31, and sought to reassure markets that the Fed and Treasury had many tools left to support the economy.

“Markets should be very comfortable that we have plenty of capacity left,” Mnuchin said, adding that the Treasury could reactivate the facilities by tapping the Exchange Stabilization Fund, a seldom-used fund housed at the department.

“To the extent these need to be reactivated, we have over $800 billion of capacity so I consider that to be a pretty good bazooka,” he said. The $800 billion would be combining the ESF and capital in remaining Federal Reserve facilities.

Mnuchin denied the move was intended to handicap the administration of Democratic President-elect Joe Biden, who will take office on Jan. 20.

“We’re not trying to hinder anything,” Mnuchin said, adding that his department would work closely with the incoming administration “if things get certified.”

He said he and White House Chief of Staff Mark Meadows would speak with congressional Republican leaders later Friday and would redouble their efforts to pass further stimulus measures.

“We want Congress to reappropriate this money,” he said.

(Reporting by Andrea Shalal and David Lawder; Editing by Chizu Nomiyama)

Pfizer is first to apply for U.S. emergency use for COVID-19 vaccine

By Vishwadha Chander

(Reuters) – Pfizer Inc. said it will apply to U.S. health regulators on Friday for emergency use authorization (EUA) of its COVID-19 vaccine, the first such application in a major step toward providing protection against the new coronavirus.

The application to the U.S. Food and Drug Administration (FDA) comes just days after Pfizer and German partner BioNTech SE reported final trial results that showed the vaccine was 95% effective in preventing COVID-19 with no major safety concerns.

Pfizer’s shares rose 1.6% and BioNTech climbed 6% on the news that a vaccine could soon be available, raising hopes for the end of a pandemic that has claimed more than a quarter of a million lives in the United States and over 1.3 million worldwide.

The application also includes safety data on about 100 children 12-15 years of age. The company said 45% of U.S. trial participants are 56-85 years old.

If the data is solid, “we literally could be weeks away from the authorization of a 95% effective vaccine,” U.S. Health Secretary Alex Azar said on CBS’ “This Morning”.

The companies expect the FDA to grant the EUA by mid-December and said they will begin shipping doses almost immediately. Pfizer has said it expects to have 50 million vaccine doses ready this year, enough to protect 25 million people.

An FDA advisory committee tentatively plans to meet Dec. 8-10 to discuss the vaccine, a source familiar with the situation told Reuters, though the dates could change.

The final trial data showed the vaccine provided a similar level of protection across different ages and ethnicities – an encouraging result as the disease disproportionately hurts the elderly and minorities.

Of the 170 volunteers who contracted COVID-19 in Pfizer’s trial involving over 43,000 people, 162 had received only a placebo, meaning the vaccine was 95% effective, far higher than originally expected. U.S. FDA had set minimum bar for efficacy of 50%.

Pfizer said nearly 42% of global participants and 30% of U.S. participants in the Phase 3 study have racially and ethnically diverse backgrounds.

“Filing in the U.S. represents a critical milestone in our journey to deliver a COVID-19 vaccine to the world and we now have a more complete picture of both the efficacy and safety profile of our vaccine,” Pfizer Chief Executive Officer Albert Bourla said in a statement.

Moderna Inc. is expected to be the next company to seek a U.S. emergency use nod for a COVID-19 vaccine. An initial analysis of data from its late-stage trial showed the vaccine was 94.5% effective. Final results and safety data are expected in the coming days or weeks.

Both the Pfizer/BioNTech and Moderna vaccines work using a new technology to trigger an immune response known as synthetic messenger RNA that can be produced at scale much more quickly than traditional vaccines.

Of dozens of drugmakers and research institutions racing to develop COVID-19 vaccines, the next late-stage data is expected to come from AstraZeneca Plc, which is working with the University of Oxford, in November or December.

Johnson & Johnson said it expects to have data needed to seek U.S. authorization for its experimental vaccine by February.

(Reporting by Vishwadha Chander in Bengaluru, additional reporting by Ankur Banerjee in Bengaluru and Doina Chiacu in Washington; Editing by Bill Berkrot, Shinjini Ganguli and Chizu Nomiyama)

Tyson Foods suspends employees after lawsuit alleges managers bet on workers catching COVID-19

By Tom Polansek

CHICAGO (Reuters) – Tyson Foods Inc. said on Thursday it suspended employees without pay and hired former U.S. Attorney General Eric Holder to conduct an investigation in response to a wrongful death lawsuit that alleges managers at an Iowa pork plant took bets on how many employees would catch COVID-19.

The coronavirus pandemic has ravaged the meatpacking industry, infecting thousands of workers since the spring and forcing companies like Tyson, Smithfield Foods and JBS to shut slaughterhouses hit by outbreaks.

The son of a worker at a Tyson facility in Waterloo, Iowa, who died in April of complications from the virus, filed a lawsuit that claims plant managers misled workers about COVID-19 and allowed sick employees to continue working.

The worker, Isidro Fernandez, got sick because of his job, according to the lawsuit that was amended on Nov. 11.

The Waterloo facility is Tyson’s largest U.S. pork plant, processing 19,500 hogs a day, or about 5% of total U.S. pork production.

COVID-19 infected more than 1,000 employees out of about 2,800 at the plant, and five died, the lawsuit says. Tyson idled the plant in late April because of an outbreak.

Earlier that month, manager Tom Hart “organized a cash buy-in, winner-take-all meatpacking industry for supervisors and managers to wager how many employees would test positive for COVID-19,” according to the lawsuit.

Hart could not immediately be reached for comment.

Tyson said it suspended employees involved in the accusations and retained the law firm Covington & Burling to conduct an independent investigation led by Holder.

“If these claims are confirmed, we’ll take all measures necessary to root out and remove this disturbing behavior from our company,” the company said.

The Iowa Capital Dispatch first reported on the betting allegations in the lawsuit on Wednesday.

“This shocking report of supervisors allegedly taking bets on how many workers would get infected, pressuring sick workers to stay on the job, and failing to enforce basic safety standards, should outrage every American,” said Marc Perrone, president of the United Food & Commercial Workers International Union.

(Reporting by Tom Polansek; Editing by Bill Berkrot)

U.S. coronavirus wildfire hitting jobs as broad recovery trudges on

By Howard Schneider

WASHINGTON (Reuters) – The most intense U.S. coronavirus outbreak yet appears to have slowed hiring and may have begun to drag on retail spending on the cusp of the holiday shopping season, even as overall economic activity proves more resilient than in the spring.

But that uneasy coexistence – wildfire-like spread of a deadly disease with an economy that remains largely open – may be tested in coming weeks if face mask mandates and lighter-touch restrictions imposed by local governments fail to curb the spread of COVID-19. Infections are growing by more than 1 million a week, according to data from the COVID Tracking Project, and the week-to-week percentage change is rising too.

Some local governments are taking more aggressive steps, with New York City again closing schools, and in a rare federal response from the “lame-duck” administration of President Donald Trump, the U.S. Centers for Disease Control and Prevention urged Americans not to travel for next week’s Thanksgiving holiday, which typically sees tens of millions on the move.

Most states, though, are moving gingerly, curbing restaurant hours or seating capacity, but not shuttering nonessential businesses like during the early months of the U.S. outbreak in the spring.

Still, the surge in cases appears to have capped the U.S. economic rebound, according to high-frequency data tracked by economists for real-time evidence about the recovery.

Employment at a sample of mostly small businesses from time management firm Homebase declined for a fourth week, and shifts worked across different industries fell, according to time management firm UKG.

“The uncertainty that exists right now and has existed really since mid-summer is making it really hard for business owners to think about growth,” said David Gilbertson, UKG vice president for strategy and operations. “We seem to take one step forward, and then one step back.”

The decline in shifts from mid-October to mid-November likely points to a weakening jobs report in November, he said.

LOOKING ‘GRIM’

Since the spring’s catastrophic drop in employment, the economy has clawed back about half of the more than 20 million lost positions. But momentum is slowing, and last week the number of new claims for unemployment insurance rose for the first time in about a month.

An index of new job postings from analytics firm Chmura as of August had reached a high of 85% of the level predicted in the absence of the pandemic, but is now at 67%.

Workers may be in for a “grim” period, said AnnElizabeth Konkel, economist at Indeed Hiring Lab, whose index of job postings remains 13% below 2019 levels. Holiday hiring is largely complete, and unemployment benefits are expiring for many of those out of work since the spring, a lapse that may finally be weighing on national data.

Initially, the flood of government support increased incomes for many families and supported consumer spending. Data on 30 million JPMorgan debit- and credit-card customers, however, showed spending fell “notably” in early November from a level just 2.7% below 2019 to 7.4% below last year, said JPMorgan economist Jesse Edgerton.

Declines were sharper in places where COVID-19 was spreading more rapidly but were still widespread, suggesting “a broader pullback in spending,” Edgerton wrote. U.S. retail sales in October also grew less than expected.

That and other data indicate an outright decline in jobs in November versus October, Edgerton said, evidence that millions left jobless by the pandemic face a long road back to normal.

SOME IMPROVEMENTS

Vaccine prospects, however, “represent a ray of light at the end of the tunnel,” said Gregory Daco, chief U.S. economist at Oxford Economics. Oxford recovery tracker rose slightly last week, snapping a five-week skid, a sign that the scale of economic collapse seen in the spring is not in the offing.

Data from OpenTable showed a slight rise in diners seated at restaurants over the past week even as new limits were imposed.

Some Federal Reserve officials have noted how businesses, particularly in manufacturing, construction and some parts of the retail sector, have adapted to operating during the pandemic. A New York Fed weekly index projecting growth in gross domestic product has risen steadily since the recession began.

But Oxford’s index and other data have also remained largely stalled, well below pre-pandemic levels. Data tracking cellphone movement from Unacast, for example, has shown no upward trend since summer.

That may remain the case until vaccines are rolled out to enough people to make a difference.

Meanwhile, “the recovery is becoming entrenched in a low-growth mode, and we are worried about signs of lasting economic damage,” Daco wrote.

(Reporting by Howard Schneider; Editing by Dan Burns and Paul Simao)

Post-Brexit UK announces largest military spending since Cold War

By Andrew MacAskill and William James

LONDON (Reuters) – Britain announced its biggest military spending increase since the Cold War on Thursday, pledging to end the “era of retreat” as it seeks a post-Brexit role in a world Prime Minister Boris Johnson warned was more perilous than for decades.

Johnson said the extra spending reflected the need to upgrade military capabilities even as the COVID-19 pandemic pummels the economy and strains public finances. He outlined plans for a new space command, an artificial intelligence agency and said the navy would be restored as Europe’s most powerful.

Outlining the first conclusions from a big review of foreign policy and defense, he announced an extra 16.5 billion pounds ($22 billion) for the military over the next four years. The defense budget is now just under 42 billion pounds a year.

“The era of cutting our defense budget must end, and it ends now,” Johnson told parliament by video link from his Downing Street office, where he is isolating after contact with someone who tested positive for COVID-19.

“I have done this in the teeth of the pandemic, amid every other demand on our resources, because the defense of the realm and the safety of the British people must come first.”

NEW GLOBAL ROLE

Britain was the main battlefield ally of the United States in Iraq and Afghanistan and, alongside France, the principal military power in the European Union. But its 2016 vote to leave the EU has made its global role uncertain at a time when China is rising and President Donald Trump has cast doubt on U.S. support for traditional allies.

The military spending announcement comes just a week after Johnson promised U.S. President-elect Joe Biden that Britain was determined to remain a valuable military ally.

Christopher Miller, acting U.S. defense secretary in Trump’s outgoing administration, welcomed the extra spending.

“The UK is our most stalwart and capable ally, and this increase in spending is indicative of their commitment to NATO and our shared security,” he said. “With this increase, the UK military will continue to be one of the finest fighting forces in the world.”

The government said the increase will cement Britain’s position as the largest defense spender in Europe and second-largest in NATO.

A national cyber force will be established alongside the new space command, which will be capable of launching its first rocket by 2022. These and other new projects will create up to 10,000 jobs, the government said.

Britain’s main opposition Labor Party said the increase was long overdue after the ruling Conservative government cut the size of the armed forces by a quarter in the last decade.

The extra funding will raise further concerns about how the government manages its defense and security budget after repeated accusations it allowed costs to spiral for overly-ambitious projects.

A report by lawmakers said on Thursday that Britain’s GCHQ spying agency ignored evidence and broke its budget in choosing an expensive central London headquarters for a newly-created cyber-security center.

After media reports that billions of pounds could be cut from Britain’s foreign aid budget, Defense Secretary Ben Wallace told Sky News that higher defense spending would not come at the expense of aid.

“It doesn’t mean to say we are abandoning the battlefield of international aid, we’re still one of the most generous givers of international aid,” Wallace said.

(Additional reporting by Elizabeth Piper in London; Editing by Catherine Evans)

COVID-19 survivors may have long lasting immunity; Pfizer vaccine is 95% effective in trial

COVID-19 survivors may have long lasting immunity; Pfizer vaccine is 95% effective in trial
By Nancy Lapid

(Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

Immune protection against severe reinfection appears lasting

Regardless of their detectable antibody levels, most COVID-19 survivors are likely to have lasting protection against severe COVID-19 if they become re-infected, thanks to other components of the body’s immune response that remember the new coronavirus in different ways, researchers say. In a study of 185 patients, including 41 who had been infected more than six months earlier, scientists at La Jolla Institute for Immunology in California found that multiple branches of the immune system – not just antibodies – recognized the novel coronavirus for at least eight months. For example, so-called memory B cells that could recognize the virus and produce antibodies to fight it were more abundant six months after infection than at one month, they reported in a paper posted on Monday on bioRxiv ahead of peer review. The new findings “suggest that the immune system can remember the virus for years, and most people may be protected from severe COVID-19 for a substantial time,” said study leaders Shane Crotty and Alessandro Sette.

Final data from Pfizer vaccine trial shows 95% efficacy

Final results from Pfizer Inc’s pivotal COVID-19 vaccine trial show it had a 95% success rate – even higher than an earlier analysis – and two months of follow-up data without serious side effects, the company said on Wednesday. In the study involving about 43,000 volunteers, 162 of the 170 who contracted COVID-19 had received a placebo, not the vaccine. Of the 10 participants who had severe COVID-19, only one had received the vaccine. The final analysis of the trial’s data comes a week after interim results showed the vaccine was more than 90% effective. Moderna Inc on Monday released preliminary data for its vaccine, showing 94.5% effectiveness. Pfizer said the efficacy its two-dose vaccine, developed with German partner BioNTech SE, was consistent across different age and ethnic groups. Efficacy in adults over age 65 was over 94%. Pfizer said it expects to make up to 50 million vaccine doses this year – enough to inoculate 25 million people – and up to 1.3 billion doses in 2021.

Respiratory muscle damage linked to severe COVID-19

Critically ill COVID-19 patients develop virus-induced damage of respiratory muscles, scientists at Amsterdam UMC in The Netherlands reported on Monday in JAMA Internal Medicine. They performed autopsy studies of the diaphragm, the main respiratory muscle, in 26 COVID-19 patients who died in the intensive care unit (ICU) and 8 ICU patients who died without COVID-19. In everyone, the diaphragm muscle cell membranes contained a protein called ACE2, which the new coronavirus uses as an entryway into cells. The researchers found genetic evidence of the virus in diaphragm muscle cells in some of those who died from COVID-19, and microscopy analyses showed much more connective tissue scarring (fibrosis) in COVID-19 patients’ diaphragms, indicating damage, study coauthor Coen Ottenheijm told Reuters. He said the diaphragm damage may help explain why it is often difficult for COVID-19 patients to breathe on their own again after they have been on mechanical ventilators in the ICU. It may also explain the persistent shortness of breath in patients recovering from COVID-19.

Cardiac arrest survival is down during the pandemic

U.S. data from early this year suggest the pandemic has led to decreased survival rates after “out-of-hospital” cardiac arrest. Based on nationwide data, the proportion of patients whose hearts could be restarted was 21% lower in March-April 2020 than in the same period in 2019, researchers reported on Saturday at the annual American Heart Association meeting, held virtually this year, and in JAMA Cardiology. The proportion of patients who survived to be discharged from hospitals was also lower in 2020, at 6.6%, versus 9.8% in 2019. Survival rates after out-of-hospital cardiac arrest had nearly doubled in the last 20 years, and “we want to make sure we don’t lose those gains,” said coauthor Dr. Paul Chan of St. Luke’s Mid-America Heart Institute in Missouri. Dr. Clifton Callaway of the University of Pittsburgh, who viewed the presentation but was not involved in the study, said other viewers noted it is more difficult for paramedics to work wearing full personal protective gear as it takes time to put on and can impede emergency care. Furthermore, some patients may have delayed calling for help over concerns of becoming infected with the coronavirus. And some may have also had COVID-19, making their medical condition more severe.

(Reporting by Nancy Lapid, Linda Carroll and Michael Erman; Editing by Bill Berkrot)

U.S. death toll from COVID-19 nears quarter million as infection rates soar

By Gabriella Borter and Anurag Maan

(Reuters) – The death toll from COVID-19 in the United States approached 250,000 on Wednesday, the day after the country recorded the highest number of victims in nearly four months, a chilling sign for a healthcare system already struggling to cope.

On Tuesday, the pandemic claimed 1,596 lives in the United States, more than on any single day since July 27, contributing to a total of 248,898 confirmed deaths since the pandemic began, according to a Reuters tally.

For weeks, health officials and healthcare workers have warned that hospitals in all regions could soon become overwhelmed, with widespread community transmission of the virus evident in many places.

“I’m the most concerned I’ve been since this pandemic started,” Dr. Tom Inglesby, director of Johns Hopkins Center for Health Security, told CNN on Wednesday.

Nationwide, the number of patients hospitalized with COVID-19 topped 75,000 on Tuesday, setting a new record. The Midwest has become the epicenter, reporting almost a half-million cases in the week ending on Monday. In Wisconsin, 90.6% of Intensive Care Unit beds were occupied as of Wednesday, state data showed.

Forty-one U.S. states have reported daily record increases in COVID-19 cases in November, 20 have registered new all-time highs in coronavirus-related deaths from day to day, and 26 have reported new peaks in hospitalizations, according to a Reuters tally of public health data.

Government officials in at least 18 states, representing both sides of the U.S. political divide, have issued sweeping new public health mandates this month. These range from stricter limits on social gatherings and non-essential businesses to new requirements for wearing masks in public places.

Even officials who initially bristled at the idea of the government imposing social restrictions have changed tune as the virus has spread.

In South Dakota, about 2% of residents currently have COVID-19, according to state data. The city of Sioux Falls voted to institute a mask mandate on Tuesday night, a week after Mayor Paul TenHaken voted the mandate down. TenHaken shifted to supporting the ordinance after the South Dakota State Medical Association urged the city council to mandate masks. State Governor Kristi Noem, a Republican, has continued to oppose government restrictions to curb COVID-19.

White House spokeswoman Kayleigh McEnany on Wednesday called the wave of new restrictions an overreach by state and local officials.

“The American people know how to protect their health,” she told Fox News in an interview. “We don’t lose our freedom in this country. We make responsible health decisions as individuals.”

(Reporting by Gabriella Borter in New York and Anurag Maan in Bengaluru; additional reporting by Susan Heavey and Maria Caspani; Editing by Rosalba O’Brien)